Table 4.

Differences in immune-activation markers between men and women

	Markers	Men [MRD ± sigma]	Women [MRD ± sigma]	p-value
CD4+	CD4+	0.03 ± 0.09	0.11 ± 0.06	0.07
	CD4+ 38+	0.11 ± 0.10	-2.29 ± 0.97	0.024†
	CD4+ 38+DR+	0.47 ± 0.10	0.36 ± 0.13	0.053
	CD4+ DR+	0.19 ± 0.16	-0.37 ± 0.83	0.052
	CD4+ NAÏVE	-6.38 ± 1.19	-5.36 ± 1.24	0.072
	CD4+ NAÏVE CD38+	0.05 ± 0.35	-1.28 ± 0.21	0.044†
	CD4+ NAÏVE	0.35 ± 0.30	1.62 ± 0.09	0.044†
	CD38+DR+	1.61 ± 0.06	-0.61 ± 0.06	0.010†
	CD4+ NAÏVE DR+	0.40 ± 0.06	0.45 ± 0.05	0.487
	CD4+ TCM	-0.19 ± 0.14	-1.72 ± 1.49	0.324
	CD4+ TCM 38+	0.16 ± 0.20	-6.23 ± 1.59	0.035†
	CD4+ TCM 38+DR+	0.72 ± 1.17	-0.19 ± 0.12	0.047†
	CD4+ TCM DR+	0.01 ± 0.18	-0.19 ± 0.24	0.523
	CD4+ TEM	0.28 ± 0.19	-5.86 ± 1.11	0.033†
	CD4+ TEM 38+	-1.23 ± 0.55	-0.32 ± 0.81	0.370
	CD4+ TEM 38+DR+	-1.40 ± 0.52	0.31 ± 0.11	0.007†
	CD4+ TEM DR+	-0.15 ± 0.08	-0.38 ± 0.11	0.094
	CD8+	0.23 ± 0.17	-4.22 ± 0.84	0.027†
CD8+	CD8+ 38+	-0.21 ± 0.24	-0.86 ± 1.19	0.060
	CD8+ 38+DR+	-0.16 ± 0.23	0.59 ± 0.08	0.010†
	CD8+ DR+	-4.05 ± 1.51	-1.06 ± 0.74	0.010†
	CD8+ NAÏVE	-0.56 ± 0.34	-8.14 ± 1.64	0.024†
	CD8+ NAÏVE CD38+	-0.29 ± 0.61	-6.21 ± 2.91	0.041†
	CD8+ NAÏVE	0.29 ± 0.08	0.76 ± 0.04	0.103
	CD38+DR+	0.48 ± 0.08	0.26 ± 0.02	0.243
	CD8+ NAÏVE DR+	0.05 ± 0.29	-4.92 ± 1.09	0.024†
	CD8+ TCM	-1.55 ± 0.60	-1.39 ± 1.48	0.923
	CD8+ TCM 38+	-0.05 ± 0.18	-1.68 ± 1.06	0.044†
	CD8+ TCM 38+DR+	-0.29 ± 0.19	-0.61 ± 0.30	0.081
	CD8+ TCM DR+	0.28 ± 0.21	-7.99 ± 0.80	0.032†
	CD8+ TEM	-4.12 ± 2.49	0.43 ± 0.02	0.010†
	CD8+ TEM 3	-1.81 ± 0.87	0.06 ± 0.04	0.007†

Columns show (1) marker name, (2) men and (3) women MRD ± sigma, and (4) p value. The statistical significance is achieved when p < 0.05^†. Data are expressed as mean ± sigma. Statistical differences between men and women patients were evaluated using Student’s t tests