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. 2020 May 1;18:83. doi: 10.1186/s12957-020-01859-y

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 4 — Knockdown NOB1 inhibited the migration, invasion, and EMT. a The expression of NOB1 was higher in osteosarcoma cell lines MG63 and SaOS2 than that of normal osteoblast cell NHOst. b siRNA-NOB1 was applied to interfere the expression of NOB1 in MG63. c The migration and invasion were decreased in NOB1 low expressed cells. d Interference of NOB1 could decrease the EMT of MG63 cells. **P < 0.01; ***P < 0.001