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. 2020 May 1;20:372. doi: 10.1186/s12885-020-06898-y

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — Gene chip detection after Prdx1 inhibition. a Changes of relevant genes in cells after inhibition of Prdx1. Negative control group: G415–1, G415–2, and G415–3. shPrdx1 group: G416–1, G416–2, and G416–3. The screening standard for a significant difference in gene expression was a value of |FC| greater than 1.3 and a P-value less than 0.05. Red signifies that the signal value of the gene is relatively up-regulated. Green signifies that the signal value of the gene is relatively down-regulated. Black signifies a moderate signal value of the gene. Grey signifies that no signal value was detected. b Differentially expressed genes in disease and cell functional classifications after Prdx1 inhibition in EC9706 cells. All diseases and cell functions were sequenced with -Log (P-value). c The effects of differentially expressed genes on cell function and diseases after Prdx1 inhibition. Orange signifies Z-score > 0. Blue signifies Z-score < 0. Grey signifies no Z-score value. Z-score > 2 signifies that the function is significantly activated. Z-score < − 2 signifies that the function is significantly inhibited