Table 1.

Effects of differentially expressed genes on disease and cell function after Prdx1 inhibition

Diseases or Functions Annotation	Activation z-score	p-Value	Differentially expressed genes (n)
Tumorigenesis of tissue	−0.137	4.02E-13	656
Proliferation of tumor cells	0.927	1.52E-10	56
Proliferation of cells	−0.89	5.22E-10	269
Migration of tumor cell lines	−0.848	1.62E-09	76
Cell proliferation of tumor cell lines	−0.281	7.1E-09	134
Microtubule dynamics	1.768	1.43E-08	106
Apoptosis of tumor cell lines	1.059	1.62E-08	108
Invasion of cells	−0.289	5.28E-08	82
Cell death of tumor cell lines	1.059	5.87E-08	127
Formation of cellular protrusions	2.545	0.00000043	82
Cell movement of carcinoma cell lines	−2.11	0.00000964	25
Migration of carcinoma cell lines	−2.082	0.0000125	22
Invasion of tumor cell lines	−0.362	0.000000636	64
Attachment of cells	2.187	0.000382	15
Engulfment of tumor cell lines	−1.75	0.000264	16
Gastrointestinal tract cancer	−0.926	0.000329	491
Extension of neurites	1.946	0.000335	18
Migration of pancreatic cancer cell lines	−1.912	0.000338	8
Development of kidney cell lines	−1.118	0.000369	7
Cell proliferation of kidney cell lines	−1.154	0.000426	18
Colony formation of lung cancer cell lines	−1.153	0.000448	8
Invasion of digestive organ tumor	−1	0.000512	8
Invasion of epithelial cell lines	−1.577	0.000598	7
Metastatic potential of tumor cell lines	−1.404	0.000738	6
Extension of cellular protrusions	1.257	0.00075	20
Apoptosis of colorectal cancer cell lines	1.064	0.000782	22
Degeneration of nervous system	−2.101	0.000892	26
Migration of prostate cancer cell lines	−1.087	0.000924	12
Degeneration of neurons	−1.153	0.00133	22
Neurodegeneration	−1.99	0.00136	27

Z-score > 2 signifies that the function is significantly activated. Z-score < −2 signifies that the function is significantly inhibited. All diseases and functions are sorted using -Log (P-value), ranking from high to the bottom according to the value of -log (p-value)