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. 2020 May 1;11:168. doi: 10.1186/s13287-020-01680-0

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — AD-MSC-conditioned medium administration recovers sciatic nerve ultrastructure in diabetic mice. a Representative bright-field images of semithin sections of sciatic nerves obtained from 26-week-old non-diabetic and diabetic mice treated with vehicle, conditioned medium derived from non-preconditioned AD-MSCs, or conditioned medium derived from DFX-preconditioned AD-MSCs. Myelinated fibers were stained with toluidine blue. b Frequency distribution histogram of myelinated fibers. c Representative electron microscopy images of ultrathin sections of sciatic nerves. Asterisks indicate fibers with disrupted myelin sheath, and arrows indicate the separation of shrunken axon from myelin sheath. d G-ratio quantification for small caliber (< 6 μm diameter) and large caliber (> 6 μm diameter) myelinated fibers of sciatic nerve. Qualitative data are presented as mean ± S.E.M. (n = 6, one way ANOVA with Tukey post-test, *p < 0.05)