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. 2020 May 1;11:168. doi: 10.1186/s13287-020-01680-0

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 6 — AD-MSC-conditioned medium administration reduces sciatic nerve inflammation in diabetic mice. a, b Representative confocal images of longitudinal sections of sciatic nerves obtained from 26-week-old non-diabetic and diabetic mice treated with vehicle, conditioned medium derived from non-preconditioned AD-MSCs, or conditioned medium derived from DFX-preconditioned AD-MSCs. T lymphocytes were detected with anti-CD3 antibody (a) while macrophages were detected with anti-CD11b antibody (b). Nuclei were stained with DAPI. Arrows indicates CD3⁺ cells or CD11b⁺ cells. c Quantification of CD3⁺ cells in sciatic nerve. Data are presented as number of CD3⁺ cells per 0.5 mm² of sciatic nerve. d Quantification of CD11b⁺ cells in sciatic nerve. Data are presented as number of CD11b⁺ cells per 0.5 mm² of sciatic nerve. e Quantification of mRNA levels of the pro-inflammatory cytokines IL-1β and TNF-α in the sciatic nerve. Data were normalized against the housekeeping gene β-actin. Quantitative data are presented as mean ± S.E.M. (n = 6, one-way ANOVA with Tukey post-test, *p < 0.05)