TABLE 2.
BT vs CG main effects on PAG-dependent rs-FC at T1
| Brain region | Side | MNI coordinates | Number of voxels | Z score | ||
|---|---|---|---|---|---|---|
| x | y | z | ||||
| BT > CG | ||||||
| Inferior temporal gyrus | R | 68 | −28 | −24 | 119 | 5.21 |
| Septal area/caudate nucleus | R/L | −4 | 16 | 4 | 478 | 5.05 |
| Amygdala/hippocampus | R | 24 | −14 | −12 | 220 | 4.88 |
| Hypothalamusa | R/L | 4 | −2 | −12 | 44 | 2.42 |
| BT < CG | ||||||
| Supramarginal gyrus | R | 58 | −46 | 30 | 1111 | 5.55 |
| Middle temporal gyrus | L | −46 | −58 | 8 | 487 | 5.14 |
| Posterior cingulate cortex/precuneus | R | 14 | −46 | 12 | 655 | 4.94 |
| Postcentral gyrus | L | −68 | −14 | 26 | 108 | 4.61 |
| Middle cingulate cortex | R | 18 | −36 | 40 | 298 | 4.59 |
| Insular cortex | R | 48 | 6 | −2 | 122 | 4.57 |
| Precentral gyrus | R | 48 | −2 | 50 | 86 | 4.51 |
| Precuneus, dorsal | R/L | −6 | −56 | 60 | 160 | 4.49 |
Abbreviations: BT, buprenorphine treatment for opioid use disorder; CG, comparison group; PAG, periaqueductal gray; rs-FC, resting-state functional connectivity.
a
Except this a priori region of interest, all regions listed above were cluster-level whole-brain corrected (family-wise error correction < .05) at voxel-wise P = .001.