TABLE 4.
Group (BT vs CG) by Time interaction effects on PAG-dependent rs-FC
| MNI coordinates | ||||||
|---|---|---|---|---|---|---|
| Brain region | Side | x | y | z | Number of voxels | Z score |
| BT > CG in T1-to-T2 increases | ||||||
| Middle temporal gyrus | R | 60 | −40 | 4 | 211 | 4.78 |
| Insular cortex | R | 48 | 10 | −6 | 110 | 4.51 |
| BT > CG in T1-to-T2 decreases | ||||||
| Precuneus, dorsal | L | −26 | −74 | 50 | 137 | 5.03 |
| Orbital frontal cortex | L | −18 | 32 | −18 | 169 | 4.84 |
| Septal area/caudate nucleus | R/L | −10 | 0 | 6 | 271 | 4.78 |
| Anterior cingulate cortex, dorsal | L | −2 | 30 | 10 | 175 | 4.58 |
Note: All regions listed above were cluster-level whole-brain corrected (family-wise error correction < .05) at voxel-wise P = .001.
Abbreviations: BT, buprenorphine treatment for opioid use disorder; CG, comparison group; PAG, periaqueductal gray; rs-FC, resting-state functional connectivity.