7. Jaques 2008 ‐ adverse events at 2 weeks.

Adverse event (possibly or probably related to treatment)	Mannitol group (n = 38)		Control group (n = 36)
	Not severe	Severe	Not severe	Severe
Upper respiratory tract infection	1	0	1	0
Diarrhoea	0	0	0	1
Gastro‐oesophageal reflux	0	0	1	0
Vomiting	2	0	0	0
Chest discomfort	2	0	1	0
Aggravation of CF symptoms	1	0	0	0
Fatigue	1	0	0	0
Anorexia	1	0	0	0
Chest wall pain	2	0	0	0
Dysgeusia	0	0	0	1
Cough	2	2	0	0
Haemoptysis	2	0	2	0
Nasal congestion	0	0	1	0
Pharynolaryngeal pain	3	0	0	0
Respiratory tract congestion	0	0	1	0
Wheeze	0	0	1	0
Total events	17	2	8	2

CF: cystic fibrosis
Study definition of "severe": incapacitating, or unable to do usual activities.