10. Minasian 2010 ‐ quality of life questionnaire (respiratory domain): change from start of treatment at 2 weeks (additional data from Pharmaxis).

Treatment arm	Adolescent and adult	Children 12 ‐ 13 years	Children 6 ‐ 11 years	Parents and caregivers	Overall
Mannitol	n = 7	n = 6	n = 4	n = 10	n = 27
Mean change	0.0	‐5.6	0.0	‐3.3	‐2.5
Dornase alfa	n = 4	n = 9	n = 3	n = 13	n = 29
Mean change	8.3	‐3.7	13.9	0.4	1.6
Dornase alfa & mannitol	n = 6	n = 5	n = 4	n = 9	n = 24
Mean change	1.9	‐15.0	‐10.4	‐12.2	‐9.0