Comparison 4. Mannitol versus dornase alfa ‐ cross‐over study of individuals with cystic fibrosis.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
4.1 FEV1 (% change from baseline)	1		Mean Difference (IV, Fixed, 95% CI)	Subtotals only
4.1.1 Up to 3 months	1	40	Mean Difference (IV, Fixed, 95% CI)	2.80 [‐4.80, 10.40]
4.2 FVC (% change from baseline)	1		Mean Difference (IV, Fixed, 95% CI)	Subtotals only
4.2.1 Up to 3 months	1	40	Mean Difference (IV, Fixed, 95% CI)	0.14 [‐0.02, 0.30]
4.3 FEF25-75 (% change from baseline)	1		Mean Difference (IV, Fixed, 95% CI)	Subtotals only
4.3.1 Up to 3 months	1	40	Mean Difference (IV, Fixed, 95% CI)	‐0.01 [‐0.23, 0.21]