Table-3.
Cox Proportional Hazard Models of Recurrence-free Survival
| Univariate Analysis | Multivariate Analysis | ||
|---|---|---|---|
| P | HR (95% CI) | P | |
| Gender | 0.298 | ||
| Age | 0.601 | ||
| Pre-Tx CEA | 0.378 | ||
| Pre-Tx cT-stage | 0.474 | ||
| Pre-Tx cN-stage | 0.256 | ||
| Pre-Tx cTNM prognostic stage groups | 0.052 | ||
| Time from Tx to Sx | 0.372 | ||
| Intratumoral budding | 0.464 | ||
| Tumor differentiation | 0.065 | ||
| Tumor infiltrating lymphocytes | 0.159 | 3.085 (1.054 – 9.024) | 0.040 |
| Type of desmoplastic reaction | 0.422 | ||
| Pathologic complete response | 0.144 | ||
| Percentage of residual tumor | 0.054 | ||
| CAP treatment response groups | 0.197 | 0.098 | |
| 0 | 1 | ||
| 1 | 1.174 (0.195 – 7.082) | ||
| 2 | 4.219 (0.837 – 21.267) | ||
| 3 | 4.324 (0.911 – 20.517) | ||
| Mitotic count/10HPF | 0.553 | ||
| ypT-stage | 0.146 | ||
| ypN-stage | 0.243 | ||
| ypTNM prognostic stage groups | 0.240 | ||
Abbreviations: HR - Hazard ratio; CI - Confidence interval; CEA - Carcinoembryonic antigen; Tx - Treatment; Sx - Surgery; TB- Tumor budding; TILs - Tumor intraepithelial lymphocytes