Table 4.
DHT regulation of non-immune-related gene ontologies in HMGECs
Ontology / Pathway | DHT genes ↑ | DHT genes ↓ | Z-score ↑ | Z-score ↓ |
---|---|---|---|---|
Biological process ontologies | ||||
Lipids | ||||
Lipid metabolic process | 89 | 41 | 6.26 | −1.81 |
Cellular lipid metabolic process | 57 | 28 | 4.44 | −1.47 |
Phosphatidylcholine biosynthetic process | 4 | 1 | 3.66 | 0.12 |
Steroid metabolic process | 25 | 12 | 3.55 | −0.6 |
Lipid biosynthetic process | 36 | 25 | 3.49 | 0.43 |
Phosphatidylcholine metabolic process | 5 | 1 | 3.43 | −0.34 |
Phospholipid metabolic process | 19 | 9 | 2.99 | −0.62 |
Lipid transport | 17 | 8 | 2.86 | −0.58 |
Regulation of lipid metabolic process | 14 | 6 | 2.86 | −0.58 |
Glycerophospholipid biosynthetic process | 9 | 5 | 2.77 | 0.41 |
Lipid localization | 18 | 9 | 2.68 | −0.6 |
Phospholipid biosynthetic process | 12 | 8 | 2.67 | 0.65 |
Glycerolipid biosynthetic process | 12 | 9 | 2.63 | 1.03 |
Lipid catabolic process | 18 | 5 | 2.26 | −2.09 |
Cellular lipid catabolic process | 11 | 3 | 2.21 | −1.41 |
Sphingolipid metabolic process | 9 | 3 | 2.17 | −0.93 |
Glycerophospholipid metabolic process | 11 | 6 | 2.12 | −0.25 |
Cholesterol efflux | 4 | 1 | 2.09 | −0.54 |
Differentiation / autophagy | ||||
Vacuole | 42 | 22 | 6.8 | 1.31 |
Macroautophagy | 8 | 1 | 6.18 | −0.34 |
Lysosome | 35 | 19 | 6.08 | 1.3 |
Lytic vacuole | 35 | 19 | 6.08 | 1.3 |
Autophagy | 13 | 3 | 5.76 | −0.25 |
Vacuole organization | 11 | 2 | 5.59 | −0.46 |
Epidermal cell differentiation | 16 | 5 | 5.56 | −0.01 |
Autophagic vacuole assembly | 6 | 1 | 5.5 | 0 |
Keratinocyte differentiation | 13 | 5 | 4.83 | 0.38 |
Vacuolar membrane | 20 | 10 | 4.81 | 0.81 |
Autophagic vacuole | 6 | 0 | 4.47 | −1.16 |
Keratinization | 8 | 2 | 4.25 | −0.19 |
Epithelial cell differentiation | 20 | 9 | 3.17 | −0.71 |
Cell cycle | ||||
Mitotic cell cycle | 22 | 94 | −2.02 | 10 |
Cell cycle phase | 23 | 97 | −2.34 | 9.42 |
Cell cycle process | 31 | 110 | −2.08 | 9.31 |
Cell cycle | 51 | 134 | −1.02 | 9.28 |
Regulation of cell cycle | 31 | 77 | 0.36 | 8.26 |
Interphase | 11 | 52 | −1.54 | 7.88 |
Interphase of mitotic cell cycle | 11 | 50 | −1.46 | 7.6 |
Mitosis | 12 | 46 | −1.08 | 6.89 |
Nuclear division | 12 | 46 | −1.08 | 6.89 |
Cell proliferation | 56 | 118 | −0.52 | 6.84 |
M phase of mitotic cell cycle | 12 | 46 | −1.2 | 6.63 |
M phase | 16 | 56 | −1.51 | 6.35 |
G1/S transition of mitotic cell cycle | 6 | 28 | −0.91 | 6.19 |
Ribosome biogenesis | 3 | 23 | −1.39 | 6.14 |
KEGG pathways | ||||
Lysosome | 24 | 5 | 7.28 | −0.85 |
Metabolic pathways | 81 | 64 | 3.69 | −0.03 |
mTOR signaling pathway | 8 | 1 | 3.36 | −1.21 |
Aldosterone-regulated sodium reabsorption | 6 | 1 | 2.71 | −0.95 |
RNA transport | 5 | 25 | −1.11 | 5.51 |
Cell cycle | 5 | 19 | −0.59 | 4.51 |
Chemokine signaling pathway | 9 | 20 | −0.27 | 2.79 |
Antigen processing and presentation | 6 | 8 | 1.41 | 2.14 |
Biological process ontologies (≥ 5 genes/category) related to lipids, differentiation / autophagy and cell cycle, as well as assorted KEGG pathways, were selected after analyses of non-transformed data. Those ontologies and pathways with a z-score > 2.0 are highlighted in bold. Terms are analogous to those described in the legend to Table 2.