Table 4.
DHT regulation of non-immune-related gene ontologies in HMGECs
| Ontology / Pathway | DHT genes ↑ | DHT genes ↓ | Z-score ↑ | Z-score ↓ |
|---|---|---|---|---|
| Biological process ontologies | ||||
| Lipids | ||||
| Lipid metabolic process | 89 | 41 | 6.26 | −1.81 |
| Cellular lipid metabolic process | 57 | 28 | 4.44 | −1.47 |
| Phosphatidylcholine biosynthetic process | 4 | 1 | 3.66 | 0.12 |
| Steroid metabolic process | 25 | 12 | 3.55 | −0.6 |
| Lipid biosynthetic process | 36 | 25 | 3.49 | 0.43 |
| Phosphatidylcholine metabolic process | 5 | 1 | 3.43 | −0.34 |
| Phospholipid metabolic process | 19 | 9 | 2.99 | −0.62 |
| Lipid transport | 17 | 8 | 2.86 | −0.58 |
| Regulation of lipid metabolic process | 14 | 6 | 2.86 | −0.58 |
| Glycerophospholipid biosynthetic process | 9 | 5 | 2.77 | 0.41 |
| Lipid localization | 18 | 9 | 2.68 | −0.6 |
| Phospholipid biosynthetic process | 12 | 8 | 2.67 | 0.65 |
| Glycerolipid biosynthetic process | 12 | 9 | 2.63 | 1.03 |
| Lipid catabolic process | 18 | 5 | 2.26 | −2.09 |
| Cellular lipid catabolic process | 11 | 3 | 2.21 | −1.41 |
| Sphingolipid metabolic process | 9 | 3 | 2.17 | −0.93 |
| Glycerophospholipid metabolic process | 11 | 6 | 2.12 | −0.25 |
| Cholesterol efflux | 4 | 1 | 2.09 | −0.54 |
| Differentiation / autophagy | ||||
| Vacuole | 42 | 22 | 6.8 | 1.31 |
| Macroautophagy | 8 | 1 | 6.18 | −0.34 |
| Lysosome | 35 | 19 | 6.08 | 1.3 |
| Lytic vacuole | 35 | 19 | 6.08 | 1.3 |
| Autophagy | 13 | 3 | 5.76 | −0.25 |
| Vacuole organization | 11 | 2 | 5.59 | −0.46 |
| Epidermal cell differentiation | 16 | 5 | 5.56 | −0.01 |
| Autophagic vacuole assembly | 6 | 1 | 5.5 | 0 |
| Keratinocyte differentiation | 13 | 5 | 4.83 | 0.38 |
| Vacuolar membrane | 20 | 10 | 4.81 | 0.81 |
| Autophagic vacuole | 6 | 0 | 4.47 | −1.16 |
| Keratinization | 8 | 2 | 4.25 | −0.19 |
| Epithelial cell differentiation | 20 | 9 | 3.17 | −0.71 |
| Cell cycle | ||||
| Mitotic cell cycle | 22 | 94 | −2.02 | 10 |
| Cell cycle phase | 23 | 97 | −2.34 | 9.42 |
| Cell cycle process | 31 | 110 | −2.08 | 9.31 |
| Cell cycle | 51 | 134 | −1.02 | 9.28 |
| Regulation of cell cycle | 31 | 77 | 0.36 | 8.26 |
| Interphase | 11 | 52 | −1.54 | 7.88 |
| Interphase of mitotic cell cycle | 11 | 50 | −1.46 | 7.6 |
| Mitosis | 12 | 46 | −1.08 | 6.89 |
| Nuclear division | 12 | 46 | −1.08 | 6.89 |
| Cell proliferation | 56 | 118 | −0.52 | 6.84 |
| M phase of mitotic cell cycle | 12 | 46 | −1.2 | 6.63 |
| M phase | 16 | 56 | −1.51 | 6.35 |
| G1/S transition of mitotic cell cycle | 6 | 28 | −0.91 | 6.19 |
| Ribosome biogenesis | 3 | 23 | −1.39 | 6.14 |
| KEGG pathways | ||||
| Lysosome | 24 | 5 | 7.28 | −0.85 |
| Metabolic pathways | 81 | 64 | 3.69 | −0.03 |
| mTOR signaling pathway | 8 | 1 | 3.36 | −1.21 |
| Aldosterone-regulated sodium reabsorption | 6 | 1 | 2.71 | −0.95 |
| RNA transport | 5 | 25 | −1.11 | 5.51 |
| Cell cycle | 5 | 19 | −0.59 | 4.51 |
| Chemokine signaling pathway | 9 | 20 | −0.27 | 2.79 |
| Antigen processing and presentation | 6 | 8 | 1.41 | 2.14 |
Biological process ontologies (≥ 5 genes/category) related to lipids, differentiation / autophagy and cell cycle, as well as assorted KEGG pathways, were selected after analyses of non-transformed data. Those ontologies and pathways with a z-score > 2.0 are highlighted in bold. Terms are analogous to those described in the legend to Table 2.