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. Author manuscript; available in PMC: 2021 Apr 1.
Published in final edited form as: Ocul Surf. 2020 Feb 27;18(2):199–205. doi: 10.1016/j.jtos.2020.02.006

Table 4.

DHT regulation of non-immune-related gene ontologies in HMGECs

Ontology / Pathway DHT genes ↑ DHT genes ↓ Z-score ↑ Z-score ↓
Biological process ontologies
Lipids
Lipid metabolic process 89 41 6.26 −1.81
Cellular lipid metabolic process 57 28 4.44 −1.47
Phosphatidylcholine biosynthetic process 4 1 3.66 0.12
Steroid metabolic process 25 12 3.55 −0.6
Lipid biosynthetic process 36 25 3.49 0.43
Phosphatidylcholine metabolic process 5 1 3.43 −0.34
Phospholipid metabolic process 19 9 2.99 −0.62
Lipid transport 17 8 2.86 −0.58
Regulation of lipid metabolic process 14 6 2.86 −0.58
Glycerophospholipid biosynthetic process 9 5 2.77 0.41
Lipid localization 18 9 2.68 −0.6
Phospholipid biosynthetic process 12 8 2.67 0.65
Glycerolipid biosynthetic process 12 9 2.63 1.03
Lipid catabolic process 18 5 2.26 −2.09
Cellular lipid catabolic process 11 3 2.21 −1.41
Sphingolipid metabolic process 9 3 2.17 −0.93
Glycerophospholipid metabolic process 11 6 2.12 −0.25
Cholesterol efflux 4 1 2.09 −0.54
Differentiation / autophagy
Vacuole 42 22 6.8 1.31
Macroautophagy 8 1 6.18 −0.34
Lysosome 35 19 6.08 1.3
Lytic vacuole 35 19 6.08 1.3
Autophagy 13 3 5.76 −0.25
Vacuole organization 11 2 5.59 −0.46
Epidermal cell differentiation 16 5 5.56 −0.01
Autophagic vacuole assembly 6 1 5.5 0
Keratinocyte differentiation 13 5 4.83 0.38
Vacuolar membrane 20 10 4.81 0.81
Autophagic vacuole 6 0 4.47 −1.16
Keratinization 8 2 4.25 −0.19
Epithelial cell differentiation 20 9 3.17 −0.71
Cell cycle
Mitotic cell cycle 22 94 −2.02 10
Cell cycle phase 23 97 −2.34 9.42
Cell cycle process 31 110 −2.08 9.31
Cell cycle 51 134 −1.02 9.28
Regulation of cell cycle 31 77 0.36 8.26
Interphase 11 52 −1.54 7.88
Interphase of mitotic cell cycle 11 50 −1.46 7.6
Mitosis 12 46 −1.08 6.89
Nuclear division 12 46 −1.08 6.89
Cell proliferation 56 118 −0.52 6.84
M phase of mitotic cell cycle 12 46 −1.2 6.63
M phase 16 56 −1.51 6.35
G1/S transition of mitotic cell cycle 6 28 −0.91 6.19
Ribosome biogenesis 3 23 −1.39 6.14
KEGG pathways
Lysosome 24 5 7.28 −0.85
Metabolic pathways 81 64 3.69 −0.03
mTOR signaling pathway 8 1 3.36 −1.21
Aldosterone-regulated sodium reabsorption 6 1 2.71 −0.95
RNA transport 5 25 −1.11 5.51
Cell cycle 5 19 −0.59 4.51
Chemokine signaling pathway 9 20 −0.27 2.79
Antigen processing and presentation 6 8 1.41 2.14

Biological process ontologies (≥ 5 genes/category) related to lipids, differentiation / autophagy and cell cycle, as well as assorted KEGG pathways, were selected after analyses of non-transformed data. Those ontologies and pathways with a z-score > 2.0 are highlighted in bold. Terms are analogous to those described in the legend to Table 2.