Table 5.
DHT up-regulation of cell cycle gene ontologies in HCECs
| Ontology | Genes ↑ | Z-score | 
|---|---|---|
| Pyrimidine ribonucleotide metabolic process | 4 | 5.62 | 
| Cell cycle process | 47 | 5.27 | 
| Mitotic cell cycle | 38 | 5.22 | 
| Cell cycle phase | 39 | 4.8 | 
| Cell cycle | 55 | 4.75 | 
| Negative regulation of cell cycle process | 8 | 4.74 | 
| Regulation of cell cycle process | 22 | 4.69 | 
| DNA-dependent DNA replication initiation | 5 | 4.33 | 
| Negative regulation of mitosis | 5 | 4.33 | 
| Negative regulation of nuclear division | 5 | 4.33 | 
| DNA-dependent DNA replication | 9 | 4.32 | 
| Regulation of cell cycle arrest | 16 | 4.3 | 
| Base-excision repair | 5 | 4.25 | 
| Spindle checkpoint | 5 | 4.25 | 
| DNA conformation change | 12 | 4.13 | 
| Mitosis | 20 | 4.09 | 
| Nuclear division | 20 | 4.09 | 
| Cell cycle checkpoint | 15 | 4.06 | 
| Cell cycle arrest | 20 | 4 | 
| Regulation of cell cycle | 30 | 3.95 | 
| Organelle fission | 20 | 3.93 | 
| M phase of mitotic cell cycle | 20 | 3.93 | 
| Pyrimidine nucleoside metabolic process | 5 | 3.85 | 
| Mitotic cell cycle checkpoint | 10 | 3.76 | 
| Double-strand break repair | 7 | 3.7 | 
| M phase | 24 | 3.61 | 
| DNA strand elongation involved in DNA replication | 4 | 3.59 | 
| Negative regulation of cell cycle | 21 | 3.58 | 
Cell cycle-related ontologies (≥ 5 genes/ontology) were selected after the analysis of biological process data. All of the ontologies listed in this Table were upregulated in HCECs following DHT treatment.