Table 5.
DHT up-regulation of cell cycle gene ontologies in HCECs
| Ontology | Genes ↑ | Z-score |
|---|---|---|
| Pyrimidine ribonucleotide metabolic process | 4 | 5.62 |
| Cell cycle process | 47 | 5.27 |
| Mitotic cell cycle | 38 | 5.22 |
| Cell cycle phase | 39 | 4.8 |
| Cell cycle | 55 | 4.75 |
| Negative regulation of cell cycle process | 8 | 4.74 |
| Regulation of cell cycle process | 22 | 4.69 |
| DNA-dependent DNA replication initiation | 5 | 4.33 |
| Negative regulation of mitosis | 5 | 4.33 |
| Negative regulation of nuclear division | 5 | 4.33 |
| DNA-dependent DNA replication | 9 | 4.32 |
| Regulation of cell cycle arrest | 16 | 4.3 |
| Base-excision repair | 5 | 4.25 |
| Spindle checkpoint | 5 | 4.25 |
| DNA conformation change | 12 | 4.13 |
| Mitosis | 20 | 4.09 |
| Nuclear division | 20 | 4.09 |
| Cell cycle checkpoint | 15 | 4.06 |
| Cell cycle arrest | 20 | 4 |
| Regulation of cell cycle | 30 | 3.95 |
| Organelle fission | 20 | 3.93 |
| M phase of mitotic cell cycle | 20 | 3.93 |
| Pyrimidine nucleoside metabolic process | 5 | 3.85 |
| Mitotic cell cycle checkpoint | 10 | 3.76 |
| Double-strand break repair | 7 | 3.7 |
| M phase | 24 | 3.61 |
| DNA strand elongation involved in DNA replication | 4 | 3.59 |
| Negative regulation of cell cycle | 21 | 3.58 |
Cell cycle-related ontologies (≥ 5 genes/ontology) were selected after the analysis of biological process data. All of the ontologies listed in this Table were upregulated in HCECs following DHT treatment.