Table 6.
DHT up-regulation of immune-related gene ontologies in HConjECs
| Ontology | Genes ↑ | Z-score |
|---|---|---|
| Myd88-dependent toll-like receptor signaling pathway | 8 | 4.78 |
| Positive regulation of defense response | 13 | 4.75 |
| Toll-like receptor signaling pathway | 9 | 4.72 |
| Pattern recognition receptor signaling pathway | 9 | 4.56 |
| Innate immune response-activating signal transduction | 9 | 4.52 |
| Activation of innate immune response | 9 | 4.44 |
| Positive regulation of innate immune response | 10 | 4.18 |
| Toll signaling pathway | 7 | 3.88 |
| Regulation of interleukin-6 production | 5 | 3.79 |
| Toll-like receptor 4 signaling pathway | 7 | 3.76 |
| Intracellular transport | 35 | 3.74 |
| Cytokine secretion | 5 | 3.73 |
| Interleukin-6 production | 5 | 3.67 |
| Toll-like receptor 1 signaling pathway | 6 | 3.46 |
| Toll-like receptor 2 signaling pathway | 6 | 3.41 |
| Regulation of defense response | 16 | 3.33 |
| Positive regulation of NF-κB transcription factor activity | 6 | 3.29 |
| Immune response-activating signal transduction | 11 | 3.25 |
| Immune response-regulating signaling pathway | 11 | 3.17 |
| Regulation of innate immune response | 10 | 3 |
| Positive regulation of immune system process | 19 | 2.95 |
| Positive regulation of immune response | 14 | 2.87 |
| Myd88-independent toll-like receptor signaling pathway | 5 | 2.82 |
| Leukocyte cell-cell adhesion | 3 | 2.82 |
| Cytokine production | 14 | 2.79 |
| Toll-like receptor 3 signaling pathway | 5 | 2.78 |
| Activation of immune response | 11 | 2.48 |
| Regulation of cytokine production | 12 | 2.4 |
| Positive regulation of response to stimulus | 27 | 2.25 |
| Positive regulation of T cell activation | 7 | 2.18 |
| Positive regulation of lymphocyte activation | 8 | 2.1 |
| Regulation of adaptive immune response based on somatic recombination of immune receptors built from | 4 | 2.08 |
| Regulation of adaptive immune response | 4 | 2.04 |
| Cytokine activity | 10 | 2.59 |
Immune-related ontologies (≥ 5 genes/ontology) were identified after the analysis of biological process and molecular function ontology data. All of the ontologies listed in this Table were upregulated in HConjECs following DHT treatment.