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. 2020 Mar 19;161(5):bqaa046. doi: 10.1210/endocr/bqaa046

Figure 8.

Figure 8

. Model: Proposed role of NR4A2 in enhancement of Prl transcriptional activity. The Prl gene is represented as a single box along with its promoter region (line). The activation process is shown as 5 hypothetical steps. 1. POU1F1 binds the Prl promoter. This binding is an initiating event and is independent of NR4A2(9). 2. POU1F1 triggers activating histone modifications at the Prl promoter (9). 3. POU1F1 recruits Pol II to the Prl promoter. This event activates transcription initiation and leads to low level Prl transcription. 4. NR4A2 binds the Prl promoter in the presence of POU1F1. The bound Nr4a2 enhances the recruitment of one or more Pol II release factor(s). 5. The efficient release of Pol II into the Prl gene body enhances transcription of the Prl gene. NR4A2, nuclear orphan receptor transcription factor; POL II, polymerase II; POU1F1, pituitary-specific master regulatory transcription factor.