Table 1. Characteristics of patients who developed postthrombolysis hemorrhage vs those without postthrombolysis hemorrhage.
| Characteristics | Patients with symptomatic postthrombolysis hemorrhage ( N = 8) | Patients without symptomatic postthrombolysis hemorrhage ( N = 52) | OR (95%CI) | p -Value |
|---|---|---|---|---|
| Abbreviations: AF, atrial fibrillation; ASPECT, Alberta Stroke Program Early CT score; BMI, body mass index; CBG, capillary blood glucose; CHADS2, congestive heart failure, hypertension, age ≥75 years, diabetes mellitus, stroke [double weight]; CI, confidence interval; EF, ejection fraction; ENI, early neurological improvement; hge, hemorrhage; LS, lacunar stroke; MABP, mean arterial blood pressure; mRS, modified Rankin scale; NIHSS, National Institute of Health Stroke Scale; OR, odds ratio; PACS, partial anterior circulation stroke; PCS, posterior circulation stroke; ref., reference (The term ‘ref’ means that the bottom tertile is considered as the reference for comparing the values of middle and upper tertile); SD, standard deviation; TACS, total anterior circulation stroke; TIA, transient ischemic attack. | ||||
| Female sex | 3 | 23 | 0.49 (0.1–2.3) | 0.45 |
| BMI (kg/m 2 ) | 24.8 (0.4) | 25.1 (0.8) | 0.30 | |
| Bottom tertile ( ref.) | 24.4–24.67, N = 2 | 24.3–25.83, N = 24 | ||
| Middle tertile | 24.68–24.95, N = 2 | 25.84–23.37, N = 17 | 1.4 (0.18–11.03) | 1.0 |
| Upper tertile | 24.96–65.6, N = 4 | 25.38–25.91, N = 11 | 4.3 (0.69–27.51) | 0.16 |
| Age | 59.9 (5.5) | 56.1 (4.5) | 0.03 | |
| Bottom tertile (ref.) | 54–57.8, N = 1 | 51.6–54.6, N = 20 | ||
| Middle tertile | 57.9–61.7, N = 1 | 54.7–57.7, N = 18 | 1.11 (0.06–19.09) | 1.0 |
| Upper tertile | 61.8–65.6, N = 6 | 57.8–60.8, N = 14 | 8.57 (0.92–79.27) | 0.04 |
| Vascular risk factors | ||||
| Previous TIA | 4 | 5 | 9.4 (1.77–49.66) | 0.01 |
| Current smoking | 2 | 13 | 1 (0.17–5.57) | 1 |
| Ischemic heart disease | 2 | 6 | 2.55 (0.41 -15.65) | 0.58 |
| AF | 3 | 3 | 9.8 (1.54–62.07) | 0.02 |
| Low EF (<35%) | 4 | 3 | 16.33 (2.67–99.90) | 0.004 |
| CHADS2 score | ||||
| 0–1 | 1 | 35 | 14.41 (1.6–126.72) | 0.005 |
| ≥2 | 7 | 17 | ||
| Bamford classification | ||||
| TACS | 4 | 7 | 6.4 (1.29–31.79) | 0.03 |
| PACS | 2 | 11 | 1.24 (0.21–7.03) | 1.0 |
| PCS | 2 | 12 | 1.11 (0.19–6.23) | 1.0 |
| LS | 0 | 22 | 0 | 0.04 |
| Mean (SD) NIHSS score postthrombolysis | 17.5 (4.0) | 11 (4) | <0.0001 | |
| Bottom tertile (ref.) | 13.5–16.83, N = 1 | 7–9.67, N = 35 | ||
| Middle tertile | 16.84–19.71, N = 3 | 9.68–12.35, N = 9 | 11.6 (1.08–125.9) | 0.04 |
| Upper tertile | 19.18–21.51, N = 4 | 12.36–15.03, N = 8 | 17.5 (1.7–178.44) | 0.01 |
| Patients thrombolysed between 3 and 4.5 h | 5 | 31 | 1.12 (0.24–5.25) | 1.0 |
| Home medications | ||||
| Antiplatelet therapy | 5 | 11 | 6.21 (1.28–30.11) | 0.02 |
| Antihypertensive therapy | 4 | 17 | 2.05 (0.45–9.24) | 0.43 |
| Anticoagulant therapy | 4 | 4 | 12 (2.14–67.06) | 0.007 |
| Statin therapy | 4 | 14 | 2.71 (0.55–12.35) | 0.22 |
| Mean (SD) ASPECT | 6.75 (1.8) | 8.2 (1.6) | 0.02 | |
| Bottom tertile (ref.) | 4.95–6.15, N = 4 | 6.6–7.67, N = 7 | ||
| Middle tertile | 6.16–7.36, N = 3 | 7.68–8.75, N = 9 | 0.58 (0.09–3.5) | 0.66 |
| Upper tertile | 7.37–8.57, N = 1 | 8.76–9.83, N = 36 | 0.04 (0.004–0.50) | 0.007 |
| SEDAN score | 3.875 (0.78) | 3.45 (0.22) | 0.0015 | |
| Bottom tertile (ref.) | 2.095–2.948, N = 2 | 3.23–376, N = 30 | ||
| Middle tertile | 2.949–3.802, N = 1 | 3.377–3.523, N = 13 | 1.15 (0.09–13.87) | 1.0 |
| Upper tertile | 3.803–4.656, N =5 | 3.524–3.670, N = 9 | 8.33 (1.37–50.47) | 0.02 |
| MABP at admission | 112.8 (7.4) | 107.0 (6.8) | 0.03 | |
| Bottom tertile (ref.) | 105.4–109.93, N = 1 | 100.2–104.73, N = 28 | ||
| Middle tertile | 109.94–114.87, N = 3 | 104.74–109.27, N = 14 | 0.16 (0.15–1.75) | 0.13 |
| Upper tertile | 114.87–119.80, N = 4 | 109.28–113.81, N = 10 | 11.2 (1.14–112.52) | 0.03 |
| CBG at admission | 174.1 (9.2) | 159.7 (10.8) | 0.007 | |
| Bottom tertile (ref.) | 164.9–171.03, N = 1 | 170.5–177.7, N = 25 | ||
| Middle tertile | 171.04–177.17, N = 2 | 177.8–185.0, N = 15 | 3.33 (0.27–39.97) | 0.55 |
| Upper tertile | 177.17–183.30, N = 5 | 185.1–192.3, N = 12 | 10.41 (1.09–99.29) | 0.02 |
| Fibrinogen (mg/dL) | 468.5 (20.85) | 441.4 (26.4) | 0.007 | |
| Bottom tertile (ref.) | 416–438, N = 1 | 415–429.2, N = 21 | ||
| Middle tertile | 439–461, N = 2 | 429.3–443.3, N = 22 | 1.81 (0.15–21.61) | 1.0 |
| Upper tertile | 462–482, N = 5 | 443.3–457.4, N = 9 | 11.66 (1.8–117.59) | 0.02 |
| Outcome | ||||
| mRS score >2 | 6 | 8 | 16.5 (2.81–96.75) | 0.0012 |
| Mortality | 3 | 1 | 30.6 (2.66–351.9) | 0.006 |