Table A1.
Sensitivity analyses of the fully-adjusted associations between analgesic use and fecundability in the Time to Conceive cohort, 2008–2016.
| Time windows | Medicationsa | FRb (95% CI) | FRc (95% CI) |
|---|---|---|---|
| Pre-ovulatory | Acetaminophen | 1.03 (0.73, 1.44) | 1.09 (0.78, 1.53) |
| Aspirin | 1.04 (0.52, 2.06) | 1.02 (0.51, 2.01) | |
| NSAID | 1.03 (0.73, 1.44) | 0.96 (0.68, 1.37) | |
| Peri-ovulatory | Acetaminophen | 0.94 (0.66, 1.34) | 1.01 (0.71, 1.44) |
| Aspirin | 1.20 (0.62, 2.29) | 1.14 (0.60, 2.16) | |
| NSAID | 1.14 (0.81, 1.62) | 1.09 (0.77, 1.54) | |
| Implantation | Acetaminophen | 1.15 (0.84, 1.59) | 1.27 (0.92, 1.74) |
| Aspirin | 1.89 (1.10, 3.26) | 1.73 (1.01, 2.97) | |
| NSAID | 1.13 (0.79, 1.64) | 1.07 (0.75, 1.51) | |
| Non-Bleeding Days | Acetaminophen | 1.14 (0.90, 1.44) | 1.19 (0.94, 1.51) |
| Aspirin | 1.10 (0.70, 1.75) | 1.14 (0.72, 1.80) | |
| NSAID | 0.97 (0.74, 1.25) | 0.93 (0.71, 1.21) |
a
The reference group for each medication are cycles in which none of that medication was reported for that particular window.
b
Sensitivity analysis of the full model, limiting each exposure variable to cycles in which at least four days of the corresponding time window was observed in the daily diary.
c
Sensitivity analysis of the full model, adjusting for gravidity.