Table A2.
Analysis of the associations between analgesic use and fecundability in the Time to Conceive cohort (2008–2016), after within-cluster resampling or multiple imputation.
| Time windows | Medicationsa | FRb (95% CI) | FRc (95% CI) |
|---|---|---|---|
| Pre-ovulatory | Acetaminophen | 1.02 (0.73, 1.43) | 1.00 (0.68, 1.47) |
| Aspirin | 1.04 (0.52, 2.08) | 1.60 (0.94, 2.73) | |
| NSAID | 1.05 (0.74, 1.49) | 1.11 (0.73, 1.70) | |
| Peri-ovulatory | Acetaminophen | 0.97 (0.68, 1.37) | 1.07 (0.73, 1.56) |
| Aspirin | 1.19 (0.62, 2.28) | 1.26 (0.65, 2.46) | |
| NSAID | 1.17 (0.83, 1.65) | 1.01 (0.64, 1.57) | |
| Implantation | Acetaminophen | 1.15 (0.84, 1.58) | 1.09 (0.72, 1.64) |
| Aspirin | 2.04 (1.23, 3.39) | 2.21 (1.33, 3.69) | |
| NSAID | 1.16 (0.81, 1.64) | 1.04 (0.68, 1.59) | |
| Non-Bleeding Days | Acetaminophen | 1.13 (0.89, 1.4 | 1.10 (0.77, 1.57) |
| Aspirin | 1.10 (0.69, 1.74) | 1.17 (0.73, 1.87) | |
| NSAID | 0.99 (0.76, 1.29) | 1.05 (0.74, 1.50) |
a
The reference group for each medication are cycles in which none of that medication was reported for that particular window.
b
Analysis based on 5 datasets formed from within-cluster resampling to account for 19 women with two attempts in the study, fully adjusted model, complete case analysis.
c
Analysis based on 20 multiply imputed datasets, N=2390.