Table 4a.
Mean annualised change in the standardised rate × 1000* of cognitive decline over a median follow-up of 11·8 years, across quartiles of total and six classes of flavonoid intake: global function cognitive domain†
| Flavonoid class | Flavonoid quartiles | P trend ‡ | |||||||
|---|---|---|---|---|---|---|---|---|---|
| Quartile 1 | Quartile 2 | Quartile 3 | Quartile 4 | ||||||
| Mean | 95 % CI | Mean | 95 % CI | Mean | 95 % CI | Mean | 95% CI | ||
| Total flavonoids§ | –18·5 | –22·8, –14·1 | –18·3 | –22·3, –14·3 | –14·8 | –18·9, –10·6 | –14·9 | –19·1, –10·7 | 0·19 |
| Flavanols | –20·1 | –24·4, –15·9 | –17·8 | –21·9, –13·7 | –14·8 | –18·9, –10·7 | –13·9 | –18·0, –9·7 | 0·04 |
| Flavones | –16·0 | –20·2, –11·9 | –16·1 | –20·1, –12·0 | –16·8 | –20·9, –12·7 | –17·6 | –21·8, –13·4 | 0·58 |
| Flavanones | –15·4 | –19·5, –11·3 | –15·7 | –19·7, –11·6 | –17·9 | –21·9, –13·8 | –17·6 | –22·0, –13·3 | 0·36 |
| Flavan-3-ols | –20·6 | –24·8, –16·3 | –17·0 | –21·0, –12·9 | –15·3 | –19·4, –11·2 | –13·7 | –17·8, –9·6 | 0·04 |
| Anthocyanins | –15·9 | –20·3, –11·5 | –16·3 | –20·4, –12·2 | –17·3 | –21·3, –13·3 | –16·9 | –20·9, –12·9 | 0·77 |
| Flavonoid polymers | –18·4 | –22·8, –14·0 | –20·0 | –24·0, –16·0 | –13·5 | –17·6, –9·5 | –14·6 | –18·7, –10·5 | 0·10 |
All values are mean least-squares annualised change in global function cognitive domain score multiplied by 1000; 95 % CIs.
Of the total 2672 observations, there were 2255 complete data for global function cognitive domain.
P-values for the test of linear trend across quartile categories were based on linear regression models with the median intake of each quartile category assigned to individuals with intake in that category, and this quartile median variable was used as a continuous measure in regression models.
Adjusted for age, sex, education, total energy intake, apo E ε4 and global function score at the beginning of the exam interval (model 1).