Table 1:
Baseline characteristics of the study population at CSD
| All patients, N=91 | History of AAs, N=43 | No AAs, N=48 | |
|---|---|---|---|
| Age | 56 ± 13 | 59 ± 13 | 54 ± 13 |
| Body mass index | 29 ± 6 | 29 ± 5 | 29 ± 6 |
| Female gender | 14 (15) | 5 (12) | 9 (19) |
| Hypertension | 52 (57) | 28 (65) | 24 (50) |
| Hyperlipidemia | 47 (52) | 23 (54) | 24 (50) |
| Diabetes | 21 (23) | 7 (16) | 14 (29) |
| TIA/Stroke | 12 (13) | 7 (16) | 5 (10) |
| Sleep Apnea Syndrome | 19 (21) | 13 (30) | 6 (12)** |
| COPD | 8 (9) | 4 (9) | 4 (8) |
| CKD (GFR <60 ml/min/m2) | 31 (34) | 16 (37) | 15 (31) |
| Creatinine (mg/dL) | 1.2 ± 0.7 | 1.3± 0.8 | 1.2 ± 0.4 |
| NICM | 68 (75) | 33 (77) | 35 (73) |
| Previous heart surgery, excluding LVAD | 24 (26) | 11 (26) | 13 (27) |
| - CABG | 9 (10) | 5 (12) | 4 (8) |
| - Aortic valve replacement | 7 (8) | 3 (7) | 4 (8) |
| - Mitral valve replacement/repair | 6 (7) | 2 (5) | 4 (8) |
| ICD | 89 (98) | 43 (100) | 46 (96) |
| CRT-D | 30 (33) | 17 (40) | 13 (27) |
| Age from first ICD implant to CSD | 5 (3–9) | 5 (2–9) | 5 (3–9) |
| Atrial lead/sensing | 76 (83) | 39 (91) | 37 (77) |
| Atrial lead | 71 (78) | 37 (86) | 34 (71) |
| NYHA Class I/II/III/IV | 9/49/27/6 (10/54/30/6) | 4/25/11/3 (9/58/26/7) | 5/24/16/3 (10/50/33/6) |
| LVAD | 3 (3) | 1 (2) | 2 (4) |
| ES history | 67 (74) | 32 (74) | 35 (73) |
| Previous VT ablation | 74 (81) | 33 (77) | 42 (85) |
| History of AAs | 43 (47) | 43 (100) | |
| - AT/AFL only | 4 (4) | 4 (9) | |
| - Paroxysmal/Persistent AF | 35 (38) | 35 (81) | |
| - Permanent AF | 4 (4) | 4 (9) | |
| Previous AT/AF ablation | 9 (10) | 9 (21) | |
| Previous AV node ablation | 3 (3) | 3 (7) | |
| Inappropriate ICD shocks | 6 (7) | 3 (7) | 3 (6) |
| - Due to atrial arrhythmias | 4 (4) | 3 (7) | 1 (2) |
| BNP at CSD admission* | 277 (83–762) | 562 (118–809) | 196 (75–682) |
| Number of sustained VT/ICD shocks in the year before CSD | 8 (4–17) | 7 (4–16) | 10 (5–17) |
Values are reported as mean ± SD, n (%), or median (interquartile range). AAs= atrial arrhythmias; AF= atrial fibrillation; AFL= atrial flutter; AT= atrial tachycardia; AV= atrioventricular; BNP= brain natriuretic peptide; CABG= coronary artery bypass graft, CKD= chronic kidney disease; COPD= chronic obstructive pulmonary disorder; CRT-D= cardiac resynchronization therapy-defibrillation; CSD= cardiac sympathetic denervation; ES= electrical storm; LVAD= left ventricular assist device, NICM= nonischemic cardiomyopathy; NYHA= New York Heart Association; TIA= transitory ischemic attack; VT= ventricular tachyarrhythmias.
BNP data was available for 60 of 91 patients.
= p<0.05 between the 2 groups (patients with and without AAs).