Table 2.
Risk of all-cause and cause specific mortality in patients with IBS and matched general population comparators
| All-cause mortality | CVD | Cancer | Psychiatric disease | |||||
|---|---|---|---|---|---|---|---|---|
| IBS | Comparators | IBS | Comparators | IBS | Comparators | IBS | Comparators | |
| N | 45 254 | 217 316 | 45 254 | 217 316 | 45 254 | 217 316 | 45 254 | 217 316 |
| Deaths, no (%) | 3290 (7.3%) | 13255 (6.1%) | 1511 (3.3%) | 6079 (2.8%) | 1058 (2.3%) | 4147 (1.9%) | 346 (0.8%) | 1759 (0.8%) |
| Follow-up years | ||||||||
| Mean (SD) | 7.7 (4.1) | 7.7 (4.1) | 6.8 (4.0) | 6.8 (4.0) | 6.8 (4.0) | 6.8 (4.0) | 6.8 (4.0) | 6.8 (4.0) |
| Median (IQR) | 7.3 (4.3-10.9) | 7.3 (4.3-10.9) | 6.4 (3.4-10.0) | 6.4 (3.4-10.0) | 6.4 (3.4-10.0) | 6.4 (3.4-10.0) | 6.4 (3.4-10.0) | 6.4 (3.4-10.0) |
| Incidence rate per 1000 PY (95% CI) | 9.4 (9.1-9.7) | 7.9 (7.8-8.0) | 4.9 (4.7-5.1) | 4.1 (4.0-4.2) | 3.4 (3.2-3.6) | 2.8 (2.7-2.9) | 1.1 (1.0-1.2) | 1.2 (1.1-1.2) |
| Hazard ratio (95% CI) | ||||||||
| Unadjusted | 1.19 (1.15-1.24) | 1.19 (1.13-1.26) | 1.22 (1.14-1.31) | 0.94 (0.84-1.06) | ||||
| Conditioned | 1.10 (1.05-1.14) | 1.06 (1.00-1.13) | 1.16 (1.08-1.24) | 0.84 (0.74-0.95) | ||||
| Adjusted I | 1.12 (1.08-1.17) | 1.09 (1.03-1.16) | 1.18 (1.10-1.26) | 0.87 (0.77-0.98) | ||||
| Adjusted II | 0.96 (0.92-1.00) | 0.92 (0.87-0.98) | 0.93 (0.86-1.00) | 0.81 (0.71-0.92) | ||||
Conditioned: Conditioned on age, sex, county, and calendar period;
Adjusted I: Conditioned and further adjusted for level of education;
Adjusted II: Adjusted I and further adjusted for baseline medical comorbidities (cancer, diabetes, CVD, and neurologic disease)
IBS, irritable bowel syndrome; CVD, cardiovascular disease; SD, standard deviation; IQR, interquartile range