Table 3.
Univariate and multivariate analyses of prognostic factors for PRS
| Variables | Univariate | Multivariate | ||||
|---|---|---|---|---|---|---|
| HR | 95% CI | P | HR | 95% CI | P | |
| Characteristics of primary HCC | ||||||
| AFP (>/≤20 ng/mL) | 1.39 | 0.87‐2.22 | .165 | |||
| Tumor size (>/≤3 cm) | 1.20 | 0.72‐2.00 | .481 | |||
| Tumor number (>/≤1) | 1.54 | 0.84‐2.79 | .160 | |||
| Tumor capsule (yes/no) | 0.93 | 0.59‐1.47 | .765 | |||
| Tumor extent (unilobar/bilobar) | 0.87 | 0.27‐2.75 | .806 | |||
| Microvessel invasion of the initial tumor (yes/no) | 1.62 | 0.89‐2.95 | .116 | |||
| Histology (well/poor and moderate) | 0.62 | 0.33‐1.15 | .127 | |||
| Surgical margin (>/≤1 cm) | 1.05 | 0.66‐11.67 | .833 | |||
| Time of Pringle's maneuver (>/≤20 min) | 1.06 | 0.63‐1.79 | .818 | |||
| Characteristics at the time of recurrence | ||||||
| Age (>/≤55 y) | 1.60 | 1.00‐2.53 | .048 | 1.78 | 1.11‐2.88 | .018 |
| Etiology (virus/others) | 2.78 | 1.41‐5.26 | .003 | 2.27 | 1.14‐4.55 | .020 |
| PLT (>/≤100×109/L) | 0.80 | 0.44‐1.46 | .467 | |||
| ALB (>/≤35 g/L) | 0.71 | 0.22‐2.26 | .564 | |||
| TBIL (>/≤17 mmol/L) | 1.27 | 0.78‐2.04 | .334 | |||
| Cirrhosis (yes/no) | 1.04 | 0.64‐1.71 | .868 | |||
| Time to recurrence (>/≤2 y) | 0.31 | 0.19‐0.51 | <.001 | 0.34 | 0.21‐0.58 | <.001 |
| Tumor size at recurrence (>/≤3 cm) | 0.97 | 0.52‐1.80 | .922 | |||
| Tumor number at recurrence (>/≤1) | 1.43 | 0.85‐2.40 | .181 | |||
| AFP at recurrence (>/≤20 ng/mL) | 2.04 | 1.30‐3.21 | .002 | 1.79 | 1.13‐2.84 | .013 |
| Treatment allocation (RHR/RFA) | 0.47 | 0.29‐0.77 | .002 | 0.54 | 0.33‐0.88 | .014 |
Abbreviations: AFP, α‐fetoprotein; ALB, albumin; CI, confidence interval; HR, hazard ratio; PLT, platelet; PRS, postrecurrence survival; RFA, radiofrequency ablation; RHR, repeat hepatic resection; TBIL, total bilirubin.