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. 2020 Mar 10;9(9):3174–3187. doi: 10.1002/cam4.2969

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© 2020 The Authors. Cancer Medicine published by John Wiley & Sons Ltd.

This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Methylation status of hub CpG sites and overall survival analysis. (A) Hypermethylation patterns of the 6 hub CpG sites in OSCC samples compared with normal samples using data of http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE38532. Normal samples (n = 40) are shown as red box and OSCC samples (n = 40) as blue box. Y axis represents methylation level. ** (P<0.01) indicates a significant difference. (B) Overall survival analysis of hub CpG sites by Kaplan‐Meier test using MethSurv. A log‐rank P < .05 was considered to indicate a significant difference. OSCC, oral squamous cell carcinoma