Table 3.

Multivariate Cox proportional hazards regression models for OS using a dataset of all cases had grade information (n = 679)

Characteristic	HR	95% CI	p value
Age (ABC diagnosis), (≥ 60 vs. < 60 years)	1.16	0.96–1.40	0.130
Treatment line of fulvestrant (4th or more vs. 3rd vs. 1st and 2nd)	1.02	0.90–1.16	0.754
ABC diagnosis to fulvestrant use (≥ 3 vs. < 3 years)	0.18	0.14–0.24	< 0.001
Prior palliative chemotherapy (yes vs. no)	1.37	1.12–1.67	0.002
PgR (positive vs. negative)	1.20	0.95–1.53	0.131
Histological or nuclear grade
(2 vs. 1)	1.28	1.04–1.59	0.021
(3 vs. 1)	1.78	1.39–2.28	< 0.001

OS overall survival, HR hazard ratio, CI confidence interval, ABC advanced breast cancer, PgR, progesterone receptor