Table 5.

Multivariate Cox proportional hazards regression models for TTF using a dataset of recurrent metastatic cases that had grade information (n = 549)

Characteristic	HR	95% CI	p value
Age (ABC diagnosis), (≥ 60 vs. < 60 years)	1.27	1.03–1.57	0.026
Treatment line of fulvestrant (4th or more vs. 3rd vs. 1st and 2nd)	1.00	0.87–1.14	0.964
ABC diagnosis to fulvestrant use (≥ 3 vs. < 3 years)	0.18	0.13–0.24	< 0.001
Prior palliative chemotherapy use (yes vs. no)	1.41	1.12–1.77	0.003
Histological or nuclear grade
(2 vs. 1)	1.21	0.95–1.53	0.122
(3 vs. 1)	1.95	1.48–2.57	< 0.001

OS overall survival, HR hazard ratio, CI confidence interval, ABC advanced breast cancer, PgR progesterone receptor HER2

^aHistological or nuclear grade data are included (n = 558)