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. 2019 Dec 9;36(2):165–178. doi: 10.1007/s10565-019-09504-5

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© The Author(s) 2019

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Fig. 2 — High-yield exosomes production from hollow-fiber bioreactor. a Yield of 3D-Exos isolated by the hollow-fiber bioreactor is ~ 7.5-fold more than conventional flask conditioned media. Protein yield = exosomal protein (μg)/original conditioned medium (mL). b Particle purity of 3D-Exos from the hollow-fiber bioreactor is ~ 6.7-fold higher than conventional 2D-Exos. Particle purity = the number of particles/exosomal protein (μg). Plots show yield for each method and the mean ± SD of all measurements (*p < 0.05; **p < 0.01)