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. 2020 Feb 11;21(3):257–274. doi: 10.1007/s10522-020-09860-4

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© The Author(s) 2020

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Fig. 2 — BCAT metabolism in the human brain. Leucine (∆) readily crosses the blood brain barrier and undergoes BCATc transamination in neuronal cells producing glutamate. Excess glutamate generated during excitation is taken up by astrocytes, where glutamate is regenerated through the glutamate/glutamine cycle. Glutamate may also be removed by endothelial cells of the vasculature. (Image generated using BioRender)