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. 2020 Feb 11;21(3):257–274. doi: 10.1007/s10522-020-09860-4

Table 1.

Current FDA approved drugs to treat AD

Drug Trade name Mode of action Treatment stage
Donepezil Aricept Acetylcholinesterase inhibitora All stages
Galantamine Razadyne Acetylcholinesterase inhibitora Mild to moderate
Rivastigmine Exelon Acetylcholinesterase inhibitora Mild to moderate
Memantine Namenda NMDA receptor antagonist Mild
Donepezil + memantine Namzaric Acetylcholinesterase inhibitor + NMDA receptor antagonistb Moderate to severe

aMay delay or slow worsening of symptoms. Effectiveness varies from person to person

bEffective in individuals with moderate to severe AD who are taking a cholinesterase inhibitor might benefit by also taking memantine