Table 2.
Correlational and linear regression analyses of circulating levels of miRNAs with common clinical, anthropometric, and metabolic features of the very-old subjects investigated.
| Traits | Log-transformed levels of microRNAs | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| miR1 | miR21 | miR34a | miR92a | miR100 | miR126 | miR130a | miR146a | miR155 | miR221 | |
| Age | −0.02; 0.922 | −0.22; 0.166 | 0.07; 0.663 | −0.16; 0.311 | −0.13; 0.412 | 0.05; 0.752 | 0.06; 0.698 | −0.01; 0.937 | −0.20; 0.208 | −0.01; 0.944 |
| Sex§ | 0.29; 0.059 | −0.21; 0.631 | 0.16; 0.603 | 0.06; 0.945 | 0.11; 0.763 | 0.26; 0.408 | 0.28; 0.642 | −0.21; 0.631 | 0.06; 0.926 | −0.57; 0.260 |
| Body fat | 0.14; 0.385 | 0.18; 0.256 | −0.07; 0.687 | 0.15; 0.363 | 0.16; 0.309 | −0.15; 0.366 | 0.21; 0.185 | 0.04; 0.830 | 0.19; 0.244 | 0.23; 0.147 |
| T2DM§ | 0.43; 0.262 | −0.41; 0.326 | −0.56; 0.070 | 0.54; 0.556 | 0.03; 0.935 | −0.20; 0.503 | −0.29; 0.623 | 0.96; 0.027 | −0.53; 0.424 | 0.06; 0.907 |
| Hypertension§ | 0.16; 0.516 | −0.08; 0.771 | −0.01; 0.954 | −0.05; 0.933 | 0.26; 0.278 | −0.17; 0.385 | 0.08; 0.840 | 0.06; 0.830 | 0.63; 0.145 | −0.16; 0.600 |
| Physical activity§ | 0.13; 0.715 | 0.12; 0.749 | −0.10; 0.727 | −0.74; 0.382 | 0.41; 0.223 | 0.08; 0.776 | −0.82; 0.138 | 0.61; 0.117 | 0.66; 0.284 | 0.10; 0.819 |
| Metabolic syndrome§ | −0.14; 0.642 | −0.17; 0.613 | −0.07; 0.767 | 1.41; 0.069 | −0.04; 0.907 | −0.24; 0.324 | 0.38; 0.434 | −0.04; 0.907 | −0.42; 0.439 | −0.20; 0.613 |
| Log C-RP | 0.05; 0.770 | −0.06; 0.710 | 0.30; 0.057 | 0.09; 0.581 | 0.11; 0.509 | −0.02; 0.919 | 0.16; 0.320 | 0.13; 0.432 | −0.06; 0.711 | 0.09; 0.577 |
| Serum creatinine | −0.07; 0.659 | −0.04; 0.826 | −0.08; 0.642 | −0.04; 0.815 | −0.22; 0.181 | −0.01; 0.992 | 0.05; 0.771 | 0.02; 0.896 | −0.01; 0.940 | −0.02; 0.886 |
| Creatinine clearance | −0.01; 0.983 | 0.01; 0.978 | 0.00; 0.998 | 0.02; 0.902 | 0.16; 0.315 | −0.06; 0.734 | −0.13; 0.436 | −0.12; 0.474 | 0.02; 0.919 | −0.05; 0.764 |
The Pearson correlation test (two continuous) or a Linear Regression Model§ (one continuous and one categorical) were used to test relationships between variables. Data are expressed as correlation index and significance level (r; P) or as beta coefficient and significance level (β; P) for correlational and regression analyses, respectively. T2DM = type 2 diabetes mellitus. C-RP = C-reactive protein. Log = logarithmically transformed.