Table 3.
Linear regression analyses of circulating levels of microRNAs with mineral content in coronary and bone territories of the very-old subjects investigated.
| Log-transformed levels of microRNAs | Log Agatston score | BMD§ | T scores§ | ||||
|---|---|---|---|---|---|---|---|
| LS | FH | FN | LS | FH | FN | ||
| miR-1-3p | 0.26; 0.320 | −0.17; 0.247 | −0.16; 0.193 | −0.07; 0.658 | −0.19; 0.237 | −0.21; 0.143 | −0.09; 0.565 |
| miR-21-5p | −0.06; 0.858 | 0.09; 0.541 | −0.12; 0.334 | −0.02; 0.868 | 0.08; 0.604 | −0.16; 0.261 | 0.02; 0.926 |
| miR-34a-5p | −0.09; 0.780 | −0.05; 0.735 | −0.36; 0.001 | −0.22; 0.130 | −0.05; 0.745 | −0.43; 0.001 | −0.24; 0.131 |
| miR-92a-3p | −0.42; 0.923 | 0.05; 0.734 | −0.13; 0.294 | −0.08; 0.583 | 0.03; 0.829 | −0.17; 0.228 | −0.05; 0.757 |
| miR-100-5p | −0.04; 0.867 | −0.04; 0.793 | 0.20; 0.092 | 0.26; 0.073 | −0.06; 0.694 | 0.23; 0.093 | 0.25; 0.109 |
| miR-126-3p | 0.44; 0.147 | 0.05; 0.753 | −0.27; 0.022 | −0.15; 0.294 | 0.05; 0.771 | −0.31; 0.022 | −0.13; 0.409 |
| miR-130a-3p | −0.81; 0.208 | 0.09; 0.545 | −0.21; 0.078 | −0.10; 0.505 | 0.10; 0.548 | −0.26; 0.059 | −0.07; 0.644 |
| miR-146a-5p | 0.13; 0.764 | −0.01; 0.954 | −0.25; 0.032 | −0.16; 0.270 | −0.01; 0.956 | −0.30; 0.027 | −0.13; 0.393 |
| miR-155-5p | 0.09; 0.787 | 0.14; 0.328 | −0.14; 0.248 | −0.17; 0.232 | 0.14; 0.387 | −0.18; 0.189 | −0.12; 0.449 |
| miR-221-3p | 1.00; 0.087 | 0.05; 0.735 | −0.22; 0.062 | −0.07; 0.618 | 0.05; 0.769 | −0.27; 0.045 | −0.06; 0.700 |
A Linear Regression Model was used, with adjustment§ to sex and to physical activity practicing. Data are expressed as beta coefficient and significance level (β; P). BMD = bone mineral density; LS–lumbarsacral; FH = femural Head; FN = femural Neck; Log = logarithmically transformed.