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. 2020 Apr 24;2020:5298483. doi: 10.1155/2020/5298483

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Copyright © 2020 Wei Ren Chen et al.

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Effects of melatonin on inflammatory response and oxidative stress in β-GP-treated VSMCs (n = 6/group). (a) Result of matrix metalloprotein 9 (MMP9) mRNA expression. (b) Result of macrophage inhibitory protein-1α (MIP1α) mRNA expression. (c) Result of interleukin-8 (IL-8) mRNA expression. (d) Result of monocyte chemotactic protein (MCP-1) level. (e) Result of tumor necrosis factor α (TNFα) level. (f) Result of interleukin-6 (IL-6) level. (g, h) MitoSOX for mitochondrial superoxide formation. (i–k) Results of glutathione peroxidase (GPx), L-glutathione (GSH), and superoxide dismutase (SOD) levels. ^∗P < 0.05 vs. Con, ^#P < 0.05 vs. β-GP, and ^&P < 0.05 vs. β-GP+Mel.