. 2020 Apr 28;14:1593–1607. doi: 10.2147/DDDT.S242883

Table 3.

In vitro Activity of Investigated Malaria Box Compounds Against Asexual Blood Stages of W2, CQ-R, and 3D7, CQ-S P. falciparum Strains and Comparison with Data in the Literature

Compound Name	P. falciparum Asexual Blood Stages IC₅₀ (µM)
	CQ-Resistant Strains							CQ-Sensitive Strains
	W2^a	Dd2^b	W2^b	K1^b	K1^c	Dd2^d	FCR3^e	3D7^a	3D7^b	HB3^b	3D7^f	3D7^f	3D7^f	3D7^g
1. MMV000662	0.133±0.069	0.053	0.049	0.066	0.074	1.258		0.120±0.050	0.049	0.058	0.262	0.37	0.343	0.037
2. MMV006429	0.132±0.038	0.073	0.077	0.079	0.039	0.16	0.074	0.123±0.003		0.062	0.213	0.385	0.3	0.033
3. MMV000642	0.070±0.002				0.051	0.046		0.117±0.012						0.02
4. MMV019266	> 8	0.079	0.062	0.153	0.582	0.844	0.044	>8	0.058	0.093				0.62
5. MMV665876	0.690±0.048	0.078	0.06	0.123	0.916	0.338	0.158	0.340±0.016		0.129	0.15	0.181	0.415	0.26
6. MMV006767	2.148±0.031	0.357	0.797	1.494		0.884	0.931	1.020±0.319	0.592	0.812				0.93
7. MMV085583	0.101±0.036	0.245	0.147	0.082	0.288	0.179	0.179	0.171±0.045	0.165	0.200	0.129	0.144		0.24
8. MMV665827	0.295±0.018			0.063	0.259	0.276		0.173±0.005	0.165	0.130				0.12
DHA	0.002±0.001							0.002±0.001
CQ	0.304±0.138							0.022±0.006

Notes: ^aOriginal data from this work. Mean ± SD of at least two experiments. ^b–g Data were generated in the laboratories of Ayong, Avery, Horrocks, Van Voorhis and Poulsen and published as original data in the review of Van Voorhis et al; Creative Commons CCO public domain dedication.10

Abbreviations: CQ, chloroquine; DHA, dihydroartemisinin.