Table 3.
Hazard Ratios and 95% Confidence Intervals for Ischemic Stroke Subtypes by Low-grade Albuminuria Among HUNT 2 Participants, (n = 7261)
| Model 1 | Model 2 | ||||||
|---|---|---|---|---|---|---|---|
| ACR, mg/mmol | Cases/Person time in years | HR | 95% CI | p for trend | HR | 95% CI | p for trend |
| Lacunar stroke | |||||||
| < 1 | 96/55733 | 1 | (ref) | 1 | (ref) | ||
| 1 - < 2 | 38/16548 | 1.19 | (0.82–1.74) | 1.09 | (0.75–1.6) | ||
| 2 - < 3 | 11/3786 | 1.45 | (0.77–2.71) | 1.25 | (0.66–2.35) | ||
| ≥ 3 | 28/6130 | 2.25 | (1.48–3.45) | < 0.001 | 1.75 | (1.12–2.72) | 0.019 |
| Cardio-embolic stroke | |||||||
| < 1 | 56/55733 | 1 | (ref) | 1 | (ref) | ||
| 1 - < 2 | 21/16548 | 0.98 | (0.59–1.62) | 0.96 | (0.58–1.6) | ||
| 2 - < 3 | 7/3786 | 1.36 | (0.62–2.98) | 1.23 | (0.56–2.73) | ||
| ≥ 3 | 12/6130 | 1.43 | (0.76–2.67) | 0.242 | 1.22 | (0.64–2.3) | 0.518 |
| Large artery atherosclerotic stroke | |||||||
| < 1 | 45/55733 | 1 | (ref) | 1 | (ref) | ||
| 1 - < 2 | 16/16548 | 1.03 | (0.58–1.83) | 0.98 | (0.55–1.76) | ||
| 2 - < 3 | 7/3786 | 1.87 | (0.84–4.16) | 1.49 | (0.66–3.35) | ||
| ≥ 3 | 12/6130 | 2 | (1.05–3.79) | 0.022 | 1.51 | (0.78–2.94) | 0.186 |
| Stroke of other determined etiology | |||||||
| < 1 | 6/55733 | 1 | (ref) | 1 | (ref) | ||
| 1 - < 2 | 2/16548 | 0.9 | (0.22–5.52) | 1 | (0.19–5.13) | ||
| 2 - < 3 | 0/3786 | ||||||
| ≥ 3 | 2/6130 | 2.4 | (0.58–14.64) | 0.353 | 2.09 | (0.37–11.72) | 0.619 |
| Stroke of undetermined etiology | |||||||
| < 1 | 183/55733 | 1 | (ref) | 1 | (ref) | ||
| 1 - < 2 | 85/16548 | 1.16 | (0.9–1.51) | 1.1 | (0.85–1.43) | ||
| 2 - < 3 | 24/3786 | 1.38 | (0.9–2.12) | 1.24 | (0.8–1.9) | ||
| ≥ 3 | 52/6130 | 1.83 | (1.34–2.49) | < 0.001 | 1.53 | (1.11–2.11) | 0.009 |
ACR Urine albumin-creatinine ratio; CI Confidence interval; HR Hazard ratio
Model 1 is age adjusted
Model 2 is additionally adjusted for sex, smoking status, educational status, BMI, EGFR, DM, systolic blood pressure, non-HDL Cholesterol, Triglycerides