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. 2020 Apr 28;12:2875–2888. doi: 10.2147/CMAR.S238093

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© 2020 Yang et al.

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EVO inhibits the Wnt/β-catenin signaling pathway. (A and B) The protein levels of β-catenin, GSK-3β, and downstream targets including c-Myc and cyclin D1 were examined in 143B cells treated with different concentrations of EVO or DMSO. β-Actin was served as a loading control. The quantitative data are presented as the mean ± SD (n=3, each group). *p<0.05, ***p<0.001 vs NC group; ^##p<0.01, ^###p<0.001 vs DMSO group. (C) The effect of EVO on the Wnt/β-catenin signaling pathway was determined using the TOP-Luc luciferase reporter gene system. The relative reporter activities were exhibited as the mean ± SD (n=3, each group). *p<0.05, ***p<0.001 vs NC group; ^###p<0.001 vs DMSO group.