Table 2.

Univariate and multivariate analysis for overall survival.

Variable	Univariate analysis					Multivariable analysis
		95% CI for Exp(B)					95%CI for Exp(B)
	HR	Lower	Upper	P value		HR	Lower	Upper	P value
MTHFD1L expression: High vs. low	6.701	2.663	16.859	<0.001*		3.927	1.518	10.16	0.005*
Gender: Male vs. female				0.575
Age(years): ≥50 vs.<50				0.337
Tumor size(cm): ≥5 vs. <5	2.48	1.417	4.338	0.001*
Pathology grade: poor vs. (Well+moderate)	5.035	2.914	8.697	<0.001*		4.516	2.552	7.99	<0.001*
TNM stage: Ⅲ+Ⅳ vs.Ⅰ+Ⅱ	4.316	2.301	8.096	<0.001*		2.463	1.265	4.794	0.008*
T stage: T3+T4 vs. T1+T2	5.364	1.671	17.218	0.005*
Lymphatic metastasis: positive vs negative	3.913	2.118	7.23	<0.001*
Metastasis: positive vs. negative	9.102	4.32	19.176	<0.001*		5.885	2.638	13.132	<0.001*