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. 2020 Apr 6;10(12):5195–5208. doi: 10.7150/thno.45017

Figure 6.

Figure 6

Radiotherapy of Au NPs on orthotopic liver tumor. (A) Fluorescent images of luciferase transfected LM3 Orthotopic liver tumor bearing mice. (B) The relative tumor weight increase fold at day 14 in different groups. (C) Survival rate of the mice bearing LM3 tumors after different treatments. (D) TUNEL, (E) H&E, and (F) Ki67 analyses of tumor tissues after various treatments. Scale bar is 300 μm. I: Control; II: 6 Gy; III: Au@Tat-R-EK; IV: Au@Tat-I-EK + 6 Gy; V: Au@Tat-R-EK + 6 Gy. The dosages of Au NPs and X-ray are 25 mg/kg and 6 Gy, respectively. * and ** indicate significant difference at P < 0.05 and P < 0.01 level, respectively.