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. 2020 Apr 6;10(12):5290–5304. doi: 10.7150/thno.42658

Figure 1.

Figure 1

Protein tyrosine phosphatase receptor type O truncated isoform (PTPROt) deficiency in liver macrophages causes decreased inflammation during nonalcoholic steatohepatitis (NASH). A. The western diet-induced and methionine-choline-deficient (MCD)-induced NASH model in wild-type and PTPROt konckout mice. B.The liver from the mice described in Figure 1A (Bar = 1 cm). Liver sections were stained with Hematoxylin and Eosin (H&E) and Oil-Red O. Original magnification, ×20. Bar = 100 μm. Statistical analysis of liver weights and the number of H&E and Oil-Red O stained signal points in the above samples. C. The levels of IL-1β, TNFα, IL-6, IL-8, IL-17, and IL-18 in liver macrophages isolated from the liver samples in Figure 1B, as detected by ELISA. D. The MCD-induced NASH model in BMT mice. E. The liver from the mice described in Figure 1D. Liver sections were stained with Hematoxylin and Eosin (H&E), Oil-Red O and Masson. Original magnification, ×20. Bar = 100 μm. Abbreviations: BM: Bone marrow; BMT: Bone Marrow Transplantation; H&E: hematoxylin-eosin staining; MCD: Methionine-choline-deficient; PTPROtΔBM: Bone marrow mononuclear-specific knockout PTPROt mice; TBI: Total body irradiation; WD: Western diet.