Figure 3.

Potentially mechanistic associations of gut microbes with circulating metabolites. Spearman's correlation of serum metabolites with gut microbes, specifically those selected by Random Forests model (RF) against the glomerular filtration rate, LEfSe (LDA, p<0.05), or both (* q<0.1, ** q<0.05, *** q<0.01). Species and metabolites in red and blue denote the CKD-enriched and -decreased markers, respectively. Numbers in superscript, 1 and 2, indicate primary and secondary bile acids, respectively. Imp., Model of Importance Variable. Data are shown as metabolites were detectable in at least 50% of samples.