Table 3.
The effect of pharmacological intervention on post ischemic maximum rate of relaxation (-dp/dtmin) in rat hearts subjected to 30 min global ischemia followed by 120 min reperfusion at different time intervals. All values are represented as absolute values of dp/dtmin in mmHg/sec. Values were represented as mean ± SD (n=6 in each group). For treatment, F (7, 200) =63.9; for time, F (4, 200) =1287; a =P<0.05 vs Basal; b =P<0.05 vs Sham; c =P<0.05 vs RIPC (remote ischemic preconditioning); d =P<0.05 vs SNP (sodium nitroprusside); e =P<0.05 vs morphine
| Group | Baseline |
Reperfusion
|
|||
|---|---|---|---|---|---|
| 5 min | 30 min | 60 min | 120 min | ||
| Sham | 2947±251 | 1234±129a | 1438±15a | 1139±132a | 952±98a |
| RIPC | 3227±258 | 1910±195a,b | 2061±192a,b | 1640±172a,b | 1383±15a,b |
| RIPC+L-NAME | 3071±228 | 1342±158a,c | 1479±123a | 1176±109a,c | 988±87a |
| SNP | 3296±272 | 2034±216a,b | 2249±228a,b | 1761±168a,b | 1442±166a,b |
| RIPC+Naloxone | 3119±243 | 1398±125a,c | 1505±129a | 1196±106a,c | 995±95a |
| Morphine | 3340±290 | 2110±22a,b | 2289±205a,b | 1812±183a,b | 1558±179a,b |
| SNP+Naloxone | 3186±263 | 1439±143a,d | 1687±182a,d | 1249±139a,d | 965±92a,d |
|
Morphine+
Glibenclamide |
3214±259 | 1562±159a,e | 1736±178a,e | 1499±145a | 1164±125a,e |