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. 2019 Jul;22(7):722–728. doi: 10.22038/ijbms.2019.33444.7987

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This is an Open Access article distributed under the terms of the Creative Commons Attribution License, (http://creativecommons.org/licenses/by/3.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Immunohistochemical analysis of positive tyrosine hydroxylase (TH) cells in the substantia nigra pars compacta (SNpc) and striatum of the brain Rats. There is a significant difference in the average of TH-positive neurons in the SNpc in all treatment groups in comparison with MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) (P≤0.05). There is no significant difference in the striatum of the Irisin treatment compared to MPTP. All values are (mean±SEM). * compared to the MPTP group (P≤0.001)