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. Author manuscript; available in PMC: 2020 May 3.
Published in final edited form as: Stem Cells. 2015 Apr 27;33(7):2196–2207. doi: 10.1002/stem.1985

Figure 7.

Figure 7.

Distinct megakaryocyte progenitors at the steady and platelet-demanding state show variable degrees of dependency on thrombopoietin/cMpl signaling. (A): Frequencies of CD41+LSK, megakaryocytic progenitor (MKP), megakaryocyte–erythroid progenitor (MEP), and PreMegE in cMpl-deficient (cMpl−/−) and heterozygous (cMpl+/−) mice. The means of quadlicates are shown. (B): The total number of each progenitor cell population in cMpl−/− and cMpl+/− mice at several time points after 5-FU treatment (n 5 4, each group). Abbreviations: LSK, lineage−Sca1+cKit+; MEP, megakaryocyte–erythroid progenitor; MKP, megakaryocytic progenitor; PreMegE, pre-megakaryocyte/erythrocyte progenitors.