Table 3.
Comparison of the diagnostic performance between the Guideline parameters and the Guideline parameters plus Eos/ (Eos and hs-CRP) (n = 989).
| Prediction models | Sensitivity (%) | Specificity (%) | PPV (%) | NPV (%) | YI (%) | CR (%) | AIC | AUC | NRI | IDI |
|---|---|---|---|---|---|---|---|---|---|---|
| Leu (≤9·5) and/or Lym (<1·1) (referred to as “Guideline”) | 97·8 | 10·2 | 48·4 | 84·4 | 8·0 | 50·8 | 1340·9 | 0·540 (0·525–0·554) | – | – |
| Guideline + Eos (<0·02) | 73·1 | 71·0 | 68·5 | 75·4 | 44·1 | 72·0 | 1161·4 | 0·731 (0·703–0·759) | 0·868 | 0·175 |
| Guideline + (Eos [<0·02] and hs-CRP [≥4·0]) | 67·9 | 78·2 | 72·8 | 73·8 | 46·1 | 73·4 | 1133·0 | 0·745 (0·718–0·772) | 0·921 | 0·202 |
The unit is mg/L for hsCRP, and 109/L for Leu, Lym, and Eos.
AIC, Akaike information criteria; AUC, area under the curve; CR, consistency rate; Eos: eosinopenia; hs-CRP, high-sensitivity C-reactive protein increased; IDI, integrated discrimination improvement; Leu: normal or decreased number of leukocytes; Lym: lymphopenia; NRI, net reclassification improvement; NPV, negative predictive value; PPV, positive predictive value; YI, Youden index.