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. 2020 May 3;52(6):971–977.e3. doi: 10.1016/j.immuni.2020.04.023

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© 2020 Elsevier Inc.

Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.

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T cell Responses to Recombinant SARS-CoV-2 Proteins in COVID-19 Convalescent Individuals

(A) Phenotypic analysis of PBMCs from representative COVID-19 patients.

(B) Summarized data on the frequencies of different immune cell subsets in COVID-19 patients. HD, healthy donors (n = 2); D-Pt, discharged patients (n = 3); F-Pt, follow-up patients (n = 5).

(C) IFN-γ ELISpot analysis of COVID-19 patients to recombinant proteins. The experiments were performed in duplicates.

(D) Correlation analysis of the NAT50 and the numbers of NP-specific T cells (n = 14).

M protease, main protease; NP, nucleocapsid protein; S-RBD, receptor binding domain of spike protein; NAT50, neutralizing antibody titers. Date are presented as mean ± SEM.