Figure 1. Clinical timelines of leptomeningeal patient cohort.

Each timeline shows the unique course of patient’s disease and treatment and provides the clinical context for each CSF sampling. The time is indicated in days unless otherwise stated and is framed around the day of LMM diagnosis (day 0). Treatments include checkpoint inhibitors, kinase inhibitors and radiation therapies. CSF cytology results indicate counts for WBCs, RBCs and protein as well as the cytology finding when available (not done/negative, atypical, suspicious or positive). A star denotes CSF sampling, and the star color indicates CSF source.