Table 1:
Therapeutic moieties available to inhibit Wnt, Hh, and Notch signaling.
| Pathway | Target | Therapeutic Moiety |
|---|---|---|
| Wnt | Extracellular ligands | SFRP1 |
| Frizzled receptor | Wnt5a | |
| Wnt-C59 | ||
| Anti-Frizzled7 antibody | ||
| LRP 5/6 receptor | iWnt peptide | |
| β-catenin | Niclosamide | |
| IWR-1 | ||
| KYA1797K | ||
| FH535 | ||
| siCTNNB1 | ||
| siBag-1 | ||
| iCRT 3/14 | ||
| PNU-74654 | ||
| Gigantol | ||
| DANCR lncRNA | ||
| β-catenin and c-Myc | miR-105 | |
| IWP-2 | ||
| DK419 | ||
| miR-200c | ||
| c-Myc | c-Myc shRNA | |
| GSK-3β | Cromolyn | |
| Pyrvinium pamoate | ||
| Wnt-1 | siWnt-1 | |
| Adavivint | ||
| Wogonin | ||
| Hh | Shh | Robotnikinin |
| Anti-Shh 5E1 antibody | ||
| Anti-Shh MEDI-5304 antibody | ||
| Ptc1 | Ant-Patched-1 antibody | |
| Smo | HhAntag | |
| Cyclopamine | ||
| Vismodegib | ||
| DHCEO | ||
| SMANT | ||
| DY131 | ||
| Itraconazole | ||
| ALLO-1/2 | ||
| Compound 5 | ||
| Jervine | ||
| Cur-61414 | ||
| SANT 1–4 | ||
| Saridegib | ||
| Sonidegib | ||
| TAK-441 | ||
| BMS-833923 | ||
| LEQ506 | ||
| PF-04449913 | ||
| LY2940680 | ||
| Vitamin D3 | ||
| BRD-6851 | ||
| SEN450 | ||
| MRT-83 | ||
| Gli1 | Quinacrine | |
| GANT61 | ||
| GANT58 | ||
| Arcyriaflavin C | ||
| Physalins F | ||
| siGli1 | ||
| Gli1/2 | HPI1–4 | |
| Gli-DNA binding | Anthothecol | |
| Glabrescione B | ||
| Arsenic trioxide | ||
| Notch | ADAM 10/17 | INCB7839 |
| INCB3619 | ||
| INCB8765 | ||
| KP457 | ||
| GM6001 | ||
| GI254023X | ||
| 8C7 antibody | ||
| D1(A12) antibody | ||
| A9(B8) antibody | ||
| MEDI3622 antibody | ||
| ADAM10 prodomain | ||
| Rapamycin | ||
| MAML1 | MAM peptide antagonist | |
| SAHM1 | ||
| Notch receptors | Notch-1 shRNA | |
| Soluble Notch1 | ||
| Soluble DLL1 | ||
| Soluble Jagged1 | ||
| Genistein | ||
| Sulforaphane | ||
| Quercetin | ||
| Curcumin | ||
| Resveratrol | ||
| miR-34a | ||
| Anti-Notch-1–3 antibody | ||
| Jagged/Delta | siJagged1 antibody | |
| Anti-DLL1–4 antibodies | ||
| Nicastrin antibody | ||
| DAPT | ||
| MRK-560 | ||
| MRK-003 | ||
| PF-03084014 | ||
| MK-0752 | ||
| BMS-906024 | ||
| DBZ (LY411575) | ||
| LY450139 | ||
| RO4929097 |