Table 1:
Comparison of demographic, substance use, comorbidity characteristics, and sepsis incidence by cancer survivorship status. Among 28,840 REGARDS participants.
| Cancer Survivors (N = 2860) | No Cancer History (N = 25,980) | ||
|---|---|---|---|
| N (%) or Mean (SD)1 | N (%) or Mean (SD)1 | p value2 | |
| Age, Mean (SD) | 69.61 (8.64) | 64.35 (9.35) | <0.01 |
| Male Gender | 1621 (56.68) | 11278 (43.41) | <0.01 |
| Race | |||
| Black | 864 (30.21) | 10920 (42.03) | <0.01 |
| White | 1996 (69.79) | 15060 (57.97) | |
| < High School Education | 370 (12.94) | 3202 (12.32) | 0.02 |
| Income ≤ $20 000 | 524 (18.32) | 4656 (17.92) | <0.01 |
| Stroke Belt Residence | 1036 (36.22) | 8971 (34.53) | <0.01 |
| Current Tobacco Use | 311 (10.87) | 3837 (14.77) | <0.01 |
| Heavy Alcohol Use | 103 (3.60) | 1066 (4.10) | 0.03 |
| Baseline Medical Condition | |||
| Atrial fibrillation | 323 (11.52) | 2140 (8.43) | <0.01 |
| Chronic lung disease | 308 (10.77) | 2345 (9.03) | <0.01 |
| Coronary artery disease | 675 (24.04) | 4390 (17.22) | <0.01 |
| Chronic kidney disease | 326 (11.40) | 2822 (10.86) | 0.38 |
| Deep vein thrombosis | 224 (7.84) | 1280 (4.95) | <0.01 |
| Diabetes | 659 (23.09) | 5820 (22.48) | 0.46 |
| Dyslipidemia | 1691 (61.63) | 14787 (59.07) | 0.01 |
| Hypertension | 1801 (63.13) | 15201 (58.66) | <0.01 |
| Myocardial infarction | 486 (17.31) | 3125 (12.26) | <0.01 |
| Obesity | 1453 (50.88) | 13917 (53.66) | 0.01 |
| Peripheral artery disease | 81 (2.83) | 558 (2.15) | 0.02 |
| Stroke | 252 (8.85) | 1578 (6.09) | <0.01 |
| Comorbidity Score1, Mean (SD) | 2.27 (1.58) | 1.97 (1.48) | <0.01 |
| Biomarkers, Median (P25, P75)‡ | |||
| hs-CRP mg/dL | 2.13 (0.97, 4.85) | 2.22 (0.95, 5.05) | 0.32 |
| ACR mcg/mg | 7.74 (4.83, 18.67) | 7.35 (4.62, 15.68) | <0.01 |
| Cystatin-C mg/dL | 0.98 (0.85, 1.18) | 0.94 (0.82, 1.11) | <0.01 |
| Baseline Medication Use | |||
| Aspirin | 1357 (47.45) | 11140 (42.88) | <0.01 |
| Statins | 942 (32.94) | 8172 (31.45) | 0.11 |
| Steroids | 112 (3.92) | 888 (3.42) | 0.17 |
| Community Variables1, Mean (SD) | |||
| Median household income | 42803 (11237) | 42690 (11448) | 0.25 |
| % Completed college | 18.65 (8.43) | 18.48 (8.42) | 0.24 |
| % Below poverty line | 16.78 (6.56) | 16.93 (6.50) | 0.13 |
| % Uninsured | 18.75 (4.84) | 18.95 (4.55) | 0.02 |
| % Unemployed | 5.41 (1.69) | 5.41 (1.64) | 0.62 |
| % Urban | 46.96 (29.33) | 46.69 (29.15) | 0.66 |
| Medical Doctors3 | 1.49 (11.92) | 1.58 (11.96) | 0.98 |
| % Adult smoking | 18.95 (4.67) | 18.80 (4.92) | 0.08 |
| % Adult obesity | 30.08 (4.93) | 30.19 (5.21) | 0.14 |
| % Mammography screening | 62.89 (5.75) | 62.60 (5.92) | 0.11 |
| % Exercise access | 72.17 (23.63) | 71.32 (24.23) | 0.20 |
| % Could not see doctor due to cost | 14.99 (4.37) | 15.23 (4.44) | 0.01 |
| % Limited access to healthy foods | 6.79 (3.95) | 6.87 (4.20) | 0.80 |
1
Mean (Standard deviation) or Median (interquartile range)
2
Estimated using χ2, ANOVA, and Wilcoxon rank-sum tests.
3
Ratio per 100,000 persons.
Biomarkers presented as median and 25th and 75th percentiles.
hs-CRP: high sensitivity C-reactive protein, ACR: albumin-creatinine ratio