Table 4:

Mediating effects ¹ of community characteristics on association between cancer survivors and incidence of first sepsis event. Among 11,430 Blacks with 457 incident sepsis events.

	Natural Indirect Effect2 (Mediation Effect)		Natural Direct Effect3		Percent Mediated4 (%) (Log Hazard Scale)
	HR	95% CI5	HR	95% CI5
Mediators
Median household income	1.001	1.000 – 1.004	2.781	2.517 – 3.101	0.06%
% Completed college	1.000	0.999 – 1.001	2.783	2.522 – 3.102	0.01%
% Below poverty line	1.000	0.998 – 1.002	2.782	2.514 – 3.108	-
% Uninsured	0.999	0.997 – 1.000	2.785	2.522 – 3.108	-
Unemployment rate	1.000	0.999 – 1.001	2.784	2.525 – 3.100	0.00%
% Urban	0.999	0.998 – 1.002	2.785	2.518 – 3.106	-
Medical Doctors6	0.998	0.997 – 0.999	2.789	2.528 – 3.101	-
% Adult smoking	1.003	1.001 – 1.005	2.776	2.523 – 3.096	0.30%
% Adult obesity	0.999	0.998 – 1.002	2.783	2.532 – 3.101	-
% Mammography screening	0.999	0.996 – 1.001	2.786	2.525 – 3.097	-
% Exercise access	1.000	0.998 – 1.001	2.781	2.531 – 3.088	0.01%
% Could not see doctor due to cost	0.999	0.998 – 0.999	2.784	2.522 – 3.103	-
% Limited access to healthy foods	0.999	0.996 – 1.001	2.784	2.534 – 3.101	-
	Total Effect (Risk of Sepsis)
	No. Sepsis Events (%)		Mean Survival Time (95% CI) 7		Hazard Ratio (95% CI) 8
Cancer Survivors	95 (11.00)		8.14 (8.02 – 8.26)		2.80 (2.22 – 3.53)
No Cancer History	362 (3.32)		9.21 (9.19 – 9.24)		Ref

¹Models adjusted for age, sex, and comorbidity score.

²Natural Indirect Effect (i.e., the effect of the cancer on sepsis incidence through the mediator)

³Natural Direct Effect (i.e., the effect of the cancer on sepsis incidence NOT through mediator)

⁴Percent Mediated = Percent of the total association between the cancer and sepsis incidence that was mediated on the log hazard scale.

⁵Confidence intervals estimated using 500 bootstrapped resamples.

⁶Ratio per 100,000 persons.

⁷Mean survival time in years.

⁸Estimated from Cox proportional hazards model - Percent mediated calculated to be <0%