Table 2.

Summary of adverse effects to enzalutamide and taselisib combination

Phase I
Toxicity Category	Toxicity Code	Relationship	Taselisib (mg)	Grade 3 (n/%)	Grade 4 (n/%)
Metabolism and nutrition	Hyperglycemia	Definite	4	3 (25.0)
Skin and subcutaneous	Rash acneiform	Definite	4	1 ( 8.3)
	Rash maculo-papular	Definite	6,8	3 (25.0)
Investigation	Elevated alkaline phos	Possible	4	1 ( 1.8)
Phase II
Toxicity Category	Toxicity Code	Relationship		Grade 3 (n/%)	Grade 4 (n/%)
Blood and lymphatic	Febrile neutropenia	Possible		1 ( 5.9)
	Anemia	Possible		1 ( 5.9)
Investigation	Elevated alkaline phos	Possible		1 ( 5.9)
Gastrointestinal disorders	Nausea	Probable		1 ( 5.9)
General disorders	Fatigue	Possible		2 (11.8)
	Fever	Possible		1 ( 5.9)
Metabolism and nutrition	Dehydration	Possible		1 ( 5.9)
Skin and subcutaneous	Rash maculo-papular	Probable		3 (17.6)	2 (11.8)
	Rash acneiform	Definite		2 (11.8)
	Pruritus	Definite		1 ( 5.9)
Vascular disorders	Hypotension	Probable		1 ( 5.9)