Table 2.
TCR V gene and CDR3 amino acid sequences of HLA-A*03:01–restricted MCPyV-specific CD8+ T-cell clones.
| MCPyV epitope | clono-type | TRBV | beta CDR3 | TRAV | alpha CDR3 | no of clones (%) | EC50ng/ml | TRB CDR3 frequency, rank in tumor |
|---|---|---|---|---|---|---|---|---|
| CT AA 32–40 | 1 | 19*00 | CASSQGFGANVLTF | 12–1*00 | CVVNGNNNDMRF | 9/19 (47%) | 7.6 | 0.81%,11 |
| 2 | 19*00 | CASVSGQGVSPLHF | 12–1*00 | CVVNNNNNDMRF | 2/19 (11%) | 23.6 | 0.17%, 49 | |
| 3 | 15*00 | CATSRDGAGLVNQPQHF | 25*00 | CAGARNDYKLSF | 2/19 (11%) | 23.4 | 0.87%, 7 | |
| 4 | 4–3*00 | CASSQDPGSSYNEQFF | 38–1*00 | CALATHTGTASKLTF | 4/19 (21%) | 12.4 | 0.02%, 527 | |
| 5 | 7–6*00 | CASSLNPGRSDSPLHF | 27*00 | CAGAIPRDDKIIF | 2/19 (11%) | 22.1 | 0.19%, 44 | |
| 35*00 | CAGHSGNTPLVF | 2/19 (11%) | ||||||
| LT AA 95–103 | 1 | 4–3*00 | CASSPNPQGANMDTQYF | 3*00 | CAVRALGNAGNMLTF | 8 of 9 | 1.9 | 0.1%, 75 |